Refine your search
Collections
Co-Authors
Year
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Sharma, Memansha
- Safety Assessment of Lincomycin Following Repeated Intramuscular Administration in Goats
Abstract Views :367 |
PDF Views:0
Authors
Affiliations
1 Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, GADVASU, Ludhiana-141004, IN
1 Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, GADVASU, Ludhiana-141004, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 22, No 3 (2015), Pagination: 92-95Abstract
A safety evaluation of lincomycin was carried out to assess clinical impact of intramuscular administration of lincomycin on various haematological and biochemical parameters in goats to establish safety profile of lincomycin. Six healthy female goats were treated with single intramuscular dose of lincomycin @10.0 mg/kg body weight. The blood samples were collected at day 0 (before administration of drugs), and on 6th day of drug administration. The hematological and plasma biochemical analysis were done. No significant alterations (p < 0.05) were found in the mean value of haematological and biochemical parameters during treatment period except for significant elevation in values of Lactate dehydrogenase and Creatinine. Repeated intramuscular administration of lincomycin (10.0 mg/kg) for 5 days in goat was found safe. Thus, lincomycin may be useful to treat bacterial diseases accompanied by fever, pain and other inflammatory condition in goats.Keywords
Goats, Lincomycin, Safety Assessment.
References
- Collignon P, Courvalin P, Aidara-Kane A. Clinical importance of antimicrobial drugs in human health. Guide to Antimicrobial Use in Animals. UK: Blackwell Publishing. 2008. p. 44–58.
- Giguere S. Lincosamides, pleuromutilins, and Streptogramins. Giguere, editor. Antimicrobial Therapy in Veterinary Medicine. 4th ed; 2006.
- Barragry TB. Veterinary drug therapy. Baltimore: Lea and Febiger; 1994. p. 251–62.
- Papich MG, Riviere JE. Chloramphenicol and derivatives, macrolides, lincosamides, and miscellaneous antimicrobials. Riviere JE, Papich MG, editors. Veterinary Pharmacology and Therapeutics. 9th ed; 2009. p. 963–5.
- Bhavsar SK, Verma MP, Thaker AM. Pharmacokinetics, tissue concentration, and safety of multiple dose intravenous administration of ciprofloxacin in cow calves. J Vet Pharmacol Toxicol. 2004; 3(1):27–34.
- Khargharia S, Barua CC, Nath N, Bhattachrya M. Blood biochemical studies of enrofloxacin in Yak after intravenous administration. Iranian J Pharmacol Therap. 2007; 6:137–8.
- Patel JH, Varia RD, Patel UD, Vihol PD, Bhavsar SK, Thaker AM. Safety of levofloxacin following repeated oral administration in white leg horn layer birds. Vet World. 2009; 2(4):137–9.
- More T. Animal clinical biochemistry. New Delhi: Kalyani Publishers; 2006.
- Brar RS, Sandhu HS, Singh A. Veterinary clinical diagnosis by laboratory methods. Ludhiana-New Delhi: Kalyani Publishers; 2000.